Research Overview
My research focuses on understanding the temporal regulation of the cell cycle through the integration of quantitative proteomics, bioinformatics, and experimental cell biology. I develop computational approaches to analyze large-scale mass spectrometry datasets and connect them to mechanistic models.
Postdoctoral Research
Temporal regulation of APC/C during mitosis
Methods
- Quantitative proteomics
- Native mass spectrometry
- Crosslinking
- Xenopus laevis egg extracts
Key Findings
- Progressive phosphorylation acts as a mitotic timing mechanism.
Tools
- MaxQuant, Peaks, DIA-NN
- Custom Python/C++ scripts
PhD Research
Quantification of proteome variations at the intact protein level
Methods
- Isotope metabolic labeling
- Signal processing
- Computational modeling
Outputs
- 3 first-author publications
- Open-source algorithms